Abstract :
The kidneys are major organs that clear the drugs. Urine is one of the primary elimination routes for drugs and metabolites to be excreted outside of the body. Most drugs are predominantly excreted via the kidneys as their metabolized products. The present study was done to investigate the histopathological impact of desloratadine doses on renal tissues, histological features, and their impact on serum lipocalin-2, Kidney function test (blood urea, and creatinine). In this study 36 Male Wistar rats have been used and divided into 3 groups (twelve for each one); group 1 (control), group 2 & group 3 treated Male Wistar rats, were orally treated with desloratadine at a dose of 0.142 mg/kg and 0.245 mg/kg in saline every day for three weeks. Al the rats were euthanized under deep anesthesia and tissue samples were obtained by perfusion fixation. After routine histological procedures, the paraffin sections were stained with hematoxylin and eosin and examined histologically. The treatment of desloratadine led to a significant decrease in the reduced serum levels of lipocaline-2, urea and creatinine. In association, desloratadine -induced deleterious histological alterations including congested blood vessels and construction with detachments of tubules from underling basement membrane. Our results point out the risk of increased renal damage due to a long-term use of desloratadine.
