Research has produced crude hMG products from the urine of postmenopausal women as an alternative hormone to glycoproteins. Urine hMG crude isolated from local Indonesian women with determination in every 75 IU divided the dose up to 10 IU each dissolved in sterile aquabidest (T0) Observations were made at the intra peritoneal injection site on 30 female white rats, with every 10 females given 1 male. After 48 hours of injection of 10 IU hMG, 10 IU hCG chorulon was injected and waited for 17 hours, then surgery was performed. Observations of histological changes in the peritoneum, kidney, liver and ovaries were divided into groups T0 (10 animals), T1 (10 animals) and T2 (10 animals). No histologic changes were found on the peritoneal surface, ren, liver as a result of injection of hMG 10 IU hMG (T0) Crude hMG dissolved in 30% Polyvinylpyrrolidone (PVP) T1 or Crude hMG in soluble propylene glycol (PG) T2 which is the real purpose of administration of PVP Solvent and PG is to obtain a single dose so that the results of gonadotropin activity are obtained for ease of use in experimental animals P> 0.05, meaning that even though 10 IU hMG was used it did not cause histological changes in the tissue studied. However, in white mouse tissue, intraperitoneal injection of hMG 10 IU in T0, T1 and T2 caused changes and growth of follicles on the surface of the ovary until ovulation occurred P> 0.05.