Abstract :
Preeclampsia is a pregnancy-specific disorder causing great morbidities and mortalities to date, clinicians have long been looking for specific methods to predict preeclampsia in women. Recent study of polymorphism of Catechol-O-methyltransferase (COMT) shows that there is a decrease in the expression of COMT in the placenta of preeclamptic patient that might be used as a predictor for preeclampsia. This study was an analytic cross sectional in 20 pregnant women with severe preeclampsia and 20 women with normal pregnancies in the Department of Obstetrics Gynecology, Prof. dr. R.D. Kandou Hospital Manado which fulfil the study criteria. After anamnesis and physical examination, the subjects’ blood serum was taken and screened by PCR to assess the COMT Val 158Met gene polymorphisms. Most of the subjects of this study are multiparous (65% in normotensive and 70% in severe preeclampsia), gestational age > 37 weeks (45%) in normotensive and 29-36 weeks (50%) in severe preeclampsia, high school education (85% in normotensive and 60% in severe preeclampsia), and housewife (85% in normotensive and 70% in severe preeclampsia). After analysis, we found a significant correlation between the incidence of severe Preeclampsia with COMT Val158Met gene polymorphisms, p = 0.031 and OR = 7.36 (95% CI = 1.34 to 40.55). There is a significant correlation between the incidence of severe Preeclampsia with COMT Val 158Met gene polymorphisms, and those who have the COMT gene polymorphism is at risk 7.4 times more likely to suffer severe preeclampsia.
