This randomized split-mouth clinical experiment was conducted to evaluate the effect of concentrated growth factors membrane(CGF) versus sub-epithelial connective tissue graft SCTG for improving root coverage of localized periodontal recession. A total of twenty sites of a localized bilateral labial periodontal recession that limited to maxillary and mandibular incisors, canine, and premolars areas selected from 10 systemically healthy patients of both sexes, their ages ranged from 20-45 years old were enrolled in the study after fulfilling the inclusion criteria. The patients were randomly divided into two groups. Group I: 10 sites were treated with SCTG. Group II: 10 sites were treated with CGF membrane. Plaque index (PI), gingival index (GI), clinical attachment level (CAL), recession height (RH), recession width (RW), digital measurements of the area of recession (RA), and height of the keratinized tissue (HKT) were recorded at baseline and 1, 3, 6 and 12 months, except for PPD & CAL which were assessed at 6 and 12 months post-surgically. Gingival thickness (GT) was recorded at baseline and after 12 months post-surgically. Percentage of root coverage (RC) was recorded at 1, 3, 6, 12 months. Both groups resulted in significant improvement in all studied parameters at all the study evaluation periods as compared to their baseline value p<0.001. There were no statistically significant differences between the two studied groups for all the studied parameters (p<0.05) except for PI at 1 month in favor of group I, RA at 6 months in favor of group II, and root coverage at 1 month in favor to group II p<0.05. There were non-significant differences between the two groups in terms of pain during surgery, improvement of root sensitivity, and the satisfaction after surgery p>0.05 with a significant difference in terms of pain scores in favor of group II where group II complained the least pain p<0.05. Within the limitation of this study, CGF membrane is comparable to SCTG in management of Miller's class II periodontal recessions with no discomfort and pain as in SCTG that shows potential clinical difficulties associated with the donor site surgery.