Concentrated Growth Factors (CGF) exhibits promising potentiality in periodontal regeneration, thus the present study was conducted to evaluate the clinical and radiographic efficacy of CGF membrane in the treatment of periodontal intra-bony defects in localized aggressive periodontitis(LAP) patients. Twenty intra-bony defects in 10 LAP patients were randomly divided into two groups 10 defects each in a split-mouth design. Group I treated by surgery + Bio-Oss bone graft + collagen membrane (Control group). Group II, treated by surgery + Bio-Oss bone graft + CGF membrane (Test group). Gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, 3, 6, and 12 months. Cone-beam computed tomography(CBCT) radiograph evaluation was taken at baseline, and 12 months’ post-operative. The two treated groups showed statistically significant improvement in all clinical parameters at 3, 6, and 12 months postsurgical compared to baseline, with statistically significant differences between them at 12 months for GI and CAL at 3 months only in favor to group II P < 0.05. Both groups displayed a significant reduction in the defect area and increase in bone density at 12 months as compared to the baseline values p < 0.05 with statistically significant differences between them at 12 months in favor of group II, p<0.05. CGF membrane is comparable to collagen membrane in the treatment of intrabony periodontal defects in LAP patients. However, CGF was found to promote better radiographic bone fill (density) than collagen membrane.