Abstract :
To investigate the comparative effects of Cannabis sativa and cannabigerolic acid in streptozotocin-(STZ) induced diabetic rats. The study was performed by using different group-normal control, diabetic control, glibenclamide 5 mg/kg p.o., Cannabis sativa (100 and 200 mg/kg p.o.) and cannabigerolic acid (50 and 100 mg/kg/ p.o.), respectively The anti-diabetic activity was assessed using blood glucose level, lipid profile and insulin, respectively. The biochemical indicator assessment was done by malondialdehyde (MDA), reduce glutathione (GSH) level, superoxide dismutase (SOD) and catalase activity (CAT). Cannabigerolic acid exhibited an antidiabetic effect by significantly decreased the level of blood glucose, regain lipid profile level, increase serum insulin level and significant (p<0.05) biochemical marker i.e. MDA, GSH, SOD and CAT as compared to Cannabis sativa. The results of the study demonstrated that the treatment with cannabigerolic acid was more potent effect compared to Cannabis sativa. Our study indicates the role of Cannabigerolic acid (CBGA) play a role in preventing diabetic complications as compare to Cannabis sativa.
