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Journal ID : TMJ-03-04-2022-11229
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Title : Assessment of the level of some interleukins for corona patients at Shifa Hospital in Kirkuk

Abstract :

Coronavirus disease 2019 (COVID‐19) caused by SARS‐CoV‐2, has emerged from Wuhan City (Hubei, China) and has become pandemic across the world. This infection can cause severe respiratory disease, Bacterial and fungal infections are complications of this viral pneumonia due to the severe damage of lung tissue, cytokine storm and immune‐paralysis caused by viral infection‐induced acute respiratory distress syndrome (ARDS). The results of current study was revealed a significant differences levels of IL-6, IL-10, and IFN-γ in COVID-19 patients, respectively on level (P<0.01). The obtained results of IL-6 and IFN-γ in female and male patients showed significant differences while IL-10 didn’t showed any significant differences on level (P<0.01) compared with control group. The results which based on age was revealed a significant differences of IL-6 at the ages 71-90 years compared with the ages range 30-70 years, and also at ages 30-50 years and 51-70 years respectively on (P<0.01). The results of IL-10 was show a significant differences in patients at the ages 30-50 years and 51-70 years respectively on level (P<0.01), so as to the control group observed significant differences in ages range 51-70 years compared with ages 30-50 and 71-90 years. The results of IFN-γ appeared a significant differences in patients at the age 30-50years compared with ages 51-70 and 71-90 years on level (P<0.01). Whereas there were no significant differences for IFN-γ between ages range51-70 years and ages range 70-90 years. While in the control group observed a significant differences in ages range71-90 years versus ages range 30-70 years on level (P<0.01) otherwise no significant differences between the ages range 30-50 and 51-70 years. Finally the current study indicated the increase of levels these cytokines (IL-6, IL-10, IFN- γ) in COVID-19 patients, the raise of cytokines and the inflammation factors lead to create the storming of cytokines which was affected with age.

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