Abstract :
Systemic endothelial dysfunction plays a key role in the pathogenesis of many cardiovascular diseases today. The article aims to assess the age-related features of the severity of systemic endothelial dysfunction in female patients with chronic heart failure. In chronic heart failure, there is an increase in the basal release of nitric oxide, which indicates that the stimulated and basal production of nitric oxide in this pathological condition is dissociated. The study included 139 patients with chronic heart failure developed due to coronary heart disease and arterial hypertension and they were divided into three age groups. The mean age was 67.1±10.6. Patients with CHF that developed as a result of various forms of cardiomyopathy and chronic rheumatic heart disease were excluded from the study. All patients underwent a comprehensive examination in the study process, which included clinical (the scale of assessment of the clinical condition) modified by V. Yu. Mareeva (2000) and the 6-minute walk test (TSW) and instrumental methods of research (EchOX). Assessment of the level of nitric oxide (NO) in patients' blood in 3 age groups showed a significant increase in its level in all groups compared to the control indicators in all groups. At the same time, the highest values were observed in the group of elderly patients. The lowest average values were determined in the middle-aged group. According to the results of the study, it can be concluded that improving the availability of endothelial nitric oxide by stimulating endothelial NO synthase is one of the objectives of effective treatment of chronic heart failure in female patients.
