05 Oct 2022
30 Sep 2022
Hypothyroidism is associated with dyslipidemia, which is the leading risk for heart disease. While OPN identified as a proinflammatory cytokine has been ensnared in an assortment of disease states. This study aimed to estimate the levels of Osteopontin (OPN) and Hs-CRP in Iraqi patients with Hypothyroidism. Furthermore, investigate if there is a relationship between these parameters with lipid profiles in hypothyroid patients. The present study includes seventy-five voluntaries split into two groups. Group 1 contained 50 hypothyroid patients, and Group 2 included 25 controls. The fasting blood samples were analyzed to estimate serum OPN, TSH, total T4, Hs-CRP levels, blood chemistry parameters (total cholesterol, triglycerides, HDL-c, LDL-c, VLDL-c). In hypothyroid patients, the serum concentration of (Hs-CRP, T-cholesterol, triglycerides, LDL-c, VLDL-c, and OPN) levels was elevated than in the control group. According to the ROC technique of OPN, the cut-off value was 6.12 (ng/ml) (sensitivity: 0.94 and 1-specificity: 0.04) as the best value. Moreover, we could not find a significant correlation between OPN and other parameters in the correlation study. At the same time, there is a positive correlation between Hs-CRP with Triglycerides and VLDL [(r=0.316, P=0.025) and (r=0.347, P=0.014)]. The results suggest that serum OPN is associated with Hypothyroidism and could be considered a diagnostic marker. Also, Hs-CRP is considered an important inflammatory marker linked between Hypothyroidism and the risk factor of cardiovascular disease.