Abstract :
Antibiotic resistance pattern of Enterobacteriaceae isolates from surgical site infections with special reference to multidrug-resistant strains. Surgical site infections (SSI) are the most common hospital-as acquired infections in developing countries. In recent years there is an increasing number of infections caused by multidrug-resistant (MDR) organisms which pose a big therapeutic challenge. The aim of the study was to study the organisms belonging to the Enterobacteriaceae causing the SSI. To study the resistance pattern of the isolates causing SSI particularly those which produce Extended spectrum β lactamases, Metallo- β lactamases & are MDR. This is a retrospective study, isolates obtained from the culture of pus received in the laboratory were studied. All pus samples from SSI were cultured and identified by standard microbiological techniques and antibiotic sensitivity was carried out on Mueller Hinton agar and interpreted according to Clinical Laboratory Standards Institute (CLSI) guidelines. E. coli (48.5%)was the most common isolate. ESBL production was noted in 39 isolates, MBL in 10 isolates. Among the Enterobacteriaceae studied, Klebsiella pneumoniae was a major strain that was MDR. Rational use of antibiotics and adhering to hospital antibiotic policy will prevent the emergence of resistant organisms. Infection surveillance and Hospital Infection Control (HIC) practices should be religiously followed to prevent the spread of these drug-resistant strains.
