Abstract :
This study aimed to investigate the possible curative effects of clove and ginger oils as an anti- arthritic, anti-inflammatory, and antioxidant on rheumatoid arthritis in rats through reducing the nuclear factor-κB expression. Arthritis will be induced by injecting rats subcutaneously with 0.1 ml Complete Freund’s adjuvant (CFA) into the footpad of the left hind paw. Clove and ginger oils were administered orally at a dose of 250 mg/kg/day and the anti-inflammatory drug (Indomethacin) at a dose of 3 mg/kg/day orally. Rats were divided into 5 groups: G1: Healthy rats, G2: untreated arthritis rats, G3: Drug treated arthritis rats, G4: Clove oil-treated arthritis rats, G5: Ginger oil-treated arthritis rats. The results of the study show that administration of clove and ginger oils (250 mg/kg/day) for 28 days markedly exhibited an anti-arthritic activity by reducing the arthritis scores, inhibiting the expression levels of TNF-α, IL-1β, IL-6, TGF-β and PGE-2, and increasing the expression of IL-10, when compared with the untreated CFA- group. The study concluded that clove and ginger oils are multi-protective agents protecting humans against oxidative stress and reducing inflammation in rheumatoid arthritis after CFA injection. However, the results revealed that ginger oil is most effective in the treatment of rheumatoid arthritis followed by clove.
