Abstract :
Ochratoxin A (OTA) is a mycotoxin found in Aspergillus or Penicillium species as a secondary metabolite. In mice, ochratoxin A was employed to produce hepatotoxicity and nephrotoxicity. As a result, the purpose of this study was to look at the harmful effects of Ochratoxin A in mice by looking at blood changes as well as changes in liver and kidney enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, and blood urea). The results demonstrated a significant decrease in hemoglobin concentration, PCV percent, and total RBCs, resulting in normocytic normochromic anemia. Due to changes in the hepatic tissue, there was a significant increase in the WBC count and a significant increase in the activities of (ALT) and (AST) in mice treated with OTA alone or with cabbage seed extract, whereas no significant differences were observed in the group treated with cabbage seed extract alone. The liver histological lesion is distinguished by congestion of the central vein, degenerative abnormalities, and a small infiltration of inflammatory cells. The deteriorating appearance in mice treated with OTA is less severe than in animals treated with cabbage seed extract alone. The cortex of the medulla of the kidney from control mice exhibited no aberrant alterations, and the cortex segment showed normal glomeruli with normal urinary tubules. Kidney sections from mice treated with OTA in conjunction with cabbage seed extract exhibit minor alterations, including degenerative changes and clod edema. When compared to the creatinine level in cabbage seed extract, the OTA group showed a significant increase, while the OTA toxin showed a significant drop. These results clearly demonstrate that OTA has a stressful effect on the hepatic and renal tissues.
