04 Dec 2023
30 Nov 2023
Knowledge regarding contraceptive use is a major factor in family planning decisions. Lately, mHealth has gained traction due to increasing technological literacy and the COVID-19 pandemic. This meta-analysis aims to study whether mHealth intervention could improve contraceptive use in reproductive-age women. We conducted a systematic literature search from Pubmed, Embase, and clinicaltrials.gov for relevant articles. Critical analysis was done using the Cochrane Risk of Bias for Clinical trial. Meta-analysis was conducted using random effects model. 12 relevant studies were included in the systematic review and meta-analysis. mHealth Intervention significantly improves contraceptive use (OR: 1.53, 95%CI: 1.16 – 2.01; p=0.003). Subgroup analysis shows that mHealth intervention is more effective in Low-Middle income countries compared to high-income countries. Additionally, app-based intervention is more effective compared to text-based or phone-based intervention. mHealth intervention is effective in improving contraceptive use in reproductive-age women.
Cochlear implant is a known neural prosthesis for children with severe to profound deafness. Meningitis causes fibrosis and ossification within the cochlea lumen (Labyrinthitis Ossificans). We present a 15-months boy with bilateral profound hearing loss, post Streptococcus meningitis. We highlighted challenges in managing this case and recommended ideal management.
Tranexamic acid is a lysine amino acid derivative and a synthetic anti-fibrinolytic agent. It suppresses plasminogen production by binding to lysine receptor sites on plasminogen. The electronic databases NCBI and PubMed, as well as studies of Google Scholar and grey literature up to 2022 in research utilizing tailored keyword searches, were all searched. Out of selected 50 articles, 7 publications were utilized following assessment. Nebulized tranexamic acid may be used to treat both major and non-massive hemoptysis caused by a variety of underlying conditions, according to some data. TA's antifibrinolytic characteristics, minimal risk of adverse effects, and inexpensive price make it an appealing off-label option for the elderly, although research and data are still lacking to back up its frequent usage in anticoagulation.
New markers needed to predict the outcome of acute leukemia. CD105 (Endoglin) and CD56 (Neural cell adhesion molecule: NCAM) have been detected in various hematopoietic neoplasms. This study was performed to determine the prognostic values of CD105 and CD56 expression by flow cytometry in patients with acute leukemia (AL). CD105 and CD56 expression were evaluated in 150 de-novo acute leukemia patients by flowcytometry before start of therapy. Of 150 acute leukemia (AL) patients, 80 (53.3%) were positive for CD105 and 50 (33.3%) were positive for CD 56. In the Acute Lymphoblastic Leukemia (ALL) group, CD105 and CD56 expressions were significantly associated with elevated Total leukocytic count (TLC) and unfavorable outcome. As regarding the Acute Myeloid leukemia (AML) group, CD105 and CD56 expressions were significantly associated with unfavorable outcome Age and CD56 were identified as independent risk factors for OS in ALL patients by multivariate analysis, whereas CD105 and CD56 were identified as OS predictors in AML patients. Regarding disease-free survival (DFS), CD56 expression and age in ALL patients, in patients with AML, CD105 and CD56 were independent risk factors for shorter DFS. CD56 and CD105 have been linked to poor outcome in acute leukemia, making them potential therapeutic targets in a subset of AML and ALL patients.
Black cumin may affect BDNF production to achieve the anti-apoptotic pathway due to its molecular structure. Black cumin as a neuroprotectant in brain injury (cerebral contusion) or trauma models is unusual. This study examined how black cumin affected BDNF neuron cells in Rattus norvegicus wistar head damage. The experimental animals were divided into the following four treatment groups: Group JH1: after the brain contusion was conducted, they were fed with black cumin extract 200 mg/kg bw every day for 7 days. After a brain contusion was conducted on Group JH2, they were given black cumin extract 300 mg/kgbw each day for seven days. Group JH3: After the brain contusion was conducted, they were fed with black cumin extract 400 mg/kg bw every day for 7 days. Group K: after the brain contusion was given Nacl 0.9% 3 ml per day for 7 days. JH3 group (400mg/kgbw) with an average BDNF (65.46 ng/ml), JH1 group (200mg/kgbb) (14.93 ng/ml) when compared to control (18.96 ng/ml), and JH2 group (300mg) with BDNF levels (22.04 ng/ml) that were nearly the same as the control. 400 mg of black cumin boosted BDNF levels dramatically (P=0.000). The higher the quantity of black cumin administered, the lower the amount of apoptosis seen (P=0.076). And as BDNF levels increased, neuronal apoptosis decreased (P = 0.004). In experimental rats who had suffered head trauma, the injection of black cumin extract led to an increase in BDNF levels. In experimental rats who had suffered head trauma, the administration of black cumin extract led to a reduction in apoptosis.