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Teikyo Medical Journal


Journal ID : TMJ-25-05-2022-11295
Total View : 457

Title : Efficacy and Safety of Melatonin Supplementation in Children with Autism Spectrum Disorder

Abstract :

Sleep disturbance is a common symptom found in children with Autism Spectrum Disorder (ASD). Sleep disturbances contribute to decreased quality of life. In addition to pharmacological treatment, non-pharmacological options could also help sleep disturbances management in pediatric patients with ASD. Melatonin is a hormone secreted by the pineal gland and contributes to the sleep-wake cycle. The effects of melatonin supplementation on sleep disturbances have been extensively reported, but its role in children with ASD is not well known. The purpose of this study was to examine the effectiveness and safety of melatonin in the management of children with autism spectrum disorder. This systematic review research includes journals from the Google Scholar, Sciencedirect, and PubMed databases according to PRISMA which include the following requirements: last 5 years, abstract available, English language, and the research method is controlled trial. The search terms used were “Melatonin” AND “Children” AND “Autism Spectrum Disorder” AND “Sleep Disturbance”. From 319 articles found, 6 journals related to melatonin were selected for further review. Melatonin supplementation is associated with reduction in symptoms of sleep disturbances in pediatric patients with ASD. Melatonin supplementation tends to be safe, where the most common symptom is temporary somnolence.

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Journal ID : TMJ-24-05-2022-11294
Total View : 441

Title : The Coronavirus Disease 2019 (COVID-19) Vaccine in Pregnancy: A Review of Current Evidence and Researches in Indonesia

Abstract :

Vaccination in pregnancy is a unique case in that there is additional consideration for the fetus. Meanwhile, the immunological adjustment made to facilitate the fetus also renders pregnant women more susceptible to infections, such as Coronavirus Disease 2019 (COVID-19), with worse outcomes. In low- and middle-income countries, including Indonesia, pregnant women also have a higher risk for death of COVID-19. Furthermore, the emergence of a new variant also raises concerns of a setback in vaccinations. In this review, current evidence related to COVID-19 vaccination in pregnancy, such as efficacy, safety, and transfer of maternal antibodies is evaluated. In addition, existing knowledge gaps regarding COVID-19 vaccination in pregnancy are also explored in this review.

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Journal ID : TMJ-22-05-2022-11293
Total View : 457

Title : Anatomical positions of Impacted Wisdom teeth in the lower jaw in young patients evaluated by 3D imaging in Kirkuk city

Abstract :

Third molars, also known as wisdom teeth, are the most distal (posterior) of the three molars found in each quadrant of the human dentition, they usually appear between the ages of 17 and 25years. Third molars should ideally erupt and be properly aligned with the rest of the teeth. However, these third molars are frequently misaligned, which can result in crowding of the teeth, damage to adjacent teeth, and, in rare cases, cystic pathology or root resorption. To describe the incidence of impaction of wisdom teeth in young patients in Kirkuk city, and study the different anatomical positions of wisdom teeth also architectural histology of wisdom teeth. Fifty patients with impacted wisdom teeth in the lower arch, with ages ranging from (17–25) years were taken from dental specialized centers and from private clinics in Kirkuk city during the period from November 2021 to February 2022. Informed permission was obtained from the Kirkuk health directorate to perform this study. All the patients with impaction are included in rage age, and above the age of 25 years were excluded from this study. After taking a CBCT for the patient, evaluation of the impacted wisdom teeth begin for all the cases which were 50 cases, firstly determine the number of wisdom teeth impacted in the lower arch either in the left or right. The 27 of patients (54 %) were female while the male was 23 patients (46%). In all 50 samples, there were 22% of cases which is 11 patients have one wisdom tooth impacted. 78% of cases which are 39 patients of the samples with two teeth impaction. This study targets the ents between the ages (17-25) with impacted lower wisdom teeth living in Kirkuk city, Iraq. The mean age, when diagnosed, was 21.84 years old. In this study, clinical data were collected from the specialized dental center in Kirkuk, which has a policy of using DPT for all new patients with impacted 3M. 1. gender prevalence in 3M impaction are more in the female than male, vertically impaction & Mesially impacted are more percentage of impaction than other types of impactions so the majority of patients were referred for surgical removal of symptomatic impacted wisdom teeth. Horizontal impaction is less than vertical & mesial impaction, The least percent of impaction is distal impact. No transverse Buccal or lingual impaction is seen in this study. Type B (OS with the level of CEJ OF the second molar) impaction is most relevant in this study. and no histological difference was seen in this study in comparison with other studies’ findings.

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Journal ID : TMJ-21-05-2022-11292
Total View : 377

Title : rRT-PCR Comparison from Upper Respiratory Tract Specimens in patient that are in contact with Confirmed Cases of SARS-CoV-2 Infection

Abstract :

SARS-CoV-2 virus is the cause of COVID-19 it was first detected in a cluster sample of patients in Hubei Province, China in December 2019. At first the cluster patient had symptoms such as a fever, cough, shortness of breath, and other non-specific symptoms. The aim of the study was to examine the positivity of nasal, nasopharyngeal and oropharynx specimens. The research subjects were contact patients with or without clinical symptoms of COVID-19 at the Health Service Facilities (Fasyankes) and the Department of Microbiology, FKUI. The data was collected by consecutive sampling specimens. Data analysis performed cross tabulation and calculation of sensitivity, specificity, PPV, and NPV. The study resulted in all contact patients aged over 18 years with or without clinical symptoms of COVID-19 who were tested at Health Service Facilities (Fasyankes) and the samples were sent to the Clinical Microbiology Laboratory (LMK) FKUI. Nasopharyngeal specimens were 34.84%, oropharyngeal specimens were 30.32%, and nasal specimens were 30.77%. The three types of specimens can be substituted for a molecular detection test as an initial diagnosis of COVID-19. RT-PCR on several types of specimens showed that nasal and oropharyngeal specimens could be used as an alternative to nasopharyngeal specimens.

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Journal ID : TMJ-20-05-2022-11291
Total View : 407

Title : UBE3A T485A mutation screening in Egyptian Children with Autism Spectrum Disorder.

Abstract :

Ubiquitin E3 ligase (UBE3A) is a protein with twofold functions as a steroid hormone receptor transcriptional coactivator and as an E3 ubiquitin ligase. UBE3A excess through gene duplication or triplication or gain-of-function mutation increases the risk for autism spectrum disorders (ASD). Our aims were, first, to screen for UBE3A T485A mutation in a cohort of Egyptian children with ASD. Second, to evaluate any associations between UBE3A T485A mutation with behavioral and psychological data of children with ASD. UBE3A T485A mutation analysis was done by real-time PCR in fifty children with ASD and fifty healthy controls. Eighteen patients with ASD (36%) have homozygous mutations, 16 patients (32%) have heterozygous mutations and 16 patients have no mutation. Our study suggested that UBE3A T485A missense mutation, may contribute to autism pathology. Future large studies will be needed on T485A point mutation that hyperactivates UBE3A and the relation of this mutation to the clinical and psychological characteristics of ASD patients.

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