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27 Jun 2024 (Vol 47 , Iss 06 )

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30 Jun 2024 (Vol 47 , Iss 06 )


Teikyo Medical Journal

Journal ID : TMJ-03-06-2022-11301
Total View : 386

Title : Amelioration of potential hazard of copper nanoparticles by bio-synthetic methods using novel Turmeric (Curcuma longa), Sumac (Rhus coriaria L.), and Vitamin B12 shelled nanostructures

Abstract :

This study was conducted to ameliorate Cu nanoparticles toxicity by biosynthetic methods using turmeric, Sumac, and vitamin B12 in core-shell or double shell nanostructures. Cu nanoparticles were biosynthesized and then used to form core-shell nanostructures with turmeric, sumac, and vitamin B12 (TurCu, SumCu, Cu+B12). TurCu and SumCu were reused for the biosynthesis of double core-shell nanostructures with vitamin B12 (TurCu+B12. SumCu+B12). Characterization of nanostructures and CuO Nanoparticles were done using XRD, TEM, SEM, DLS, and zeta sizer. Female mice were used to determine LD50 of acute exposure to intraperitoneal injection of different nanostructures. To evaluate the chronic toxicity of nanostructures, other group of female mice were exposed to daily injections of 10, 20, or 30 mg/kg b.wt for each and compared to the same doses of CuO nanoparticles and normal control group. CBC, liver, and kidney functions were measured in serum and Cu deposition in liver and kidney tissues was determined. Characterization of nanostructures indicated the successful synthesis of core-shell and double core-shell form within the nanoscale. Biochemical analyses revealed that injection of CuO nanoparticles caused dose-depended toxic effects compared to control group. On the other hand, injection with any of the core-shell structures significantly (P<0.05) modulated CBC, liver function, and kidney function tests with a non-significant reduction in liver and kidney Cu deposition compared to CuO groups. TurCu has the least toxic effect compared to the other core-shell nanostructures. Meanwhile, vitamin B12 as a double core-shell has a positive effect on CBC but negatively affected liver and kidney toxicity.

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Journal ID : TMJ-02-06-2022-11300
Total View : 452

Title : A comparative laboratory study to evaluate the marginal fit of two types of temporary prostheses.

Abstract :

Comparison of the marginal fit of temporary crowns made by the direct method and those made by the indirect method (CAD-CAM). When we prepare the teeth, we remove some of tooth tissues or restorations form the abutment. and after we finish the preparation the tooth will be uncover and we can't make a proper final restoration immediately because of the time that we need to manufacture the restoration in the laboratory so the practices should give their patient a provisional restoration covers the space of the final one. so that the provisional restoration consider as a main part in treatment plan for fixed prosthodontics patient and this restoration must have a good marginal fit, and after the adhesive it reduce the marginal leakage to protect the abutment and periodontal tissue. The research sample consisted of / 40 / newly extracted premolars that were divided randomly into two equal groups according to the method used in the manufacture of temporary restoration as follows: (The first group: restoration by the direct method (Trantemp) (The second group: restoration by the the indirect method (PMMA)). The marginal applicability was evaluated under stereo microscope. The results showed that the indirect temporary restoration has achieved better marginal fit, where the marginal gap was less compared with direct temporary restoration. The indirect temporary prostheses (PMMA) achieved better marginal fit than the other types used in the study.

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Journal ID : TMJ-31-05-2022-11299
Total View : 398

Title : The Impact of Specialized Diabetes Foot Care Services Provided by Student Pharmacists at a Student Run Free Clinic

Abstract :

The student pharmacist led Diabetes Care Clinic (DCC) program provides comprehensive diabetes education, medication review, and free diabetic footwear and diabetic supplies to patients at a Student-Run Free Clinic. A Retrospective study was designed by using data collected from patient assessment sheets completed by student pharmacists assessing for foot related disorders during each diabetic patient encounter from 2010 to 2019. Over a period of 10 years, 798 student pharmacists have volunteered and reported 1208 patient encounter hours. A total of 258 diabetic patients were seen and 118 patients with foot related disorders were identified. Fungal foot infections (47%), neuropathy (29%) and foot deformities (15%) were the most prevalent and least common were foot ulcers (6%) and amputations (2.5%). DCC program is a unique learning and teaching model for student pharmacists. Interventions performed by student pharmacists’ results in positive patient outcomes and may lower the risk of diabetes foot related complications.

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Journal ID : TMJ-28-05-2022-11298
Total View : 480

Title : Estimation of Vitamin D and HbA1c Among Obese Type 2 Diabetic Patients

Abstract :

Diabetes is a metabolic disorder that can affect nearly all organ systems in the body. Recently, Vitamin D3 was given some importance worldwide in the pathogenesis of diabetes. Deficiency in vitamin D3 appears to be linked to the development of type II diabetes and metabolic syndrome. To estimate the serum levels of Vitamin D and HbA1c among obese type II diabetic patients., and to find out the relationship between BMI with serum levels of Vitamin D and HbA1c among study participants. A cross-sectional study design for a period extended from 25th December 2021 to 10th February 2022, a total of 40 obese type II diabetes patients was selected from Al-Wafa Medical Center by non-probability sampling at Mosul city in Northern Iraq. The estimation of vitamin D and HbA1c was done by using CL900i and BS230Mindray. Statistical Package for Social Sciences (SPSS) version 26 was used for statistical data analysis. Obese type II diabetes patients exhibited a highly significant decrease (at P-value < 0.001) in the serum level of vitamin D (t = 17.852) with a mean (12.2180 ± 4.32852). A positive correlation (r =0.899) between HbA1c level and BMI, and an inverse correlation (r = -0.867) between vitamin D and body mass index (BMI) at P-value < 0.001. Low vitamin D levels and elevated HbA1c are common in obese type II diabetic patients. A positive correlation between HbA1C and body mass index (BMI) and vitamin D inversely correlate with body mass index (BMI).

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Journal ID : TMJ-28-05-2022-11297
Total View : 463

Title : The effect of a six-minute walking test on glucose levels among patients with type 2 diabetes

Abstract :

Postprandial glucose is regulated by skeletal muscle movement, and exercise is the cornerstone of T2D therapy as it improves glucose uptake and metabolism in skeletal muscles. The ability to perform functional exercises is determined through (6MWT). To investigate the effect of 6mwt on glucose levels in patients with type 2 diabetes as well as to compare their functional abilities with healthy controls. Using a purposive sampling strategy, this case-control study included 62 subjects: 31 with T2DM and 31 with healthy controls. All the participants were nonsmokers with no pulmonary problems that could have influenced the 6MWT.Age, sex, and BMI were matched to each T2DM and healthy controls. We assessed demographic, anthropometric, biochemical, and physical parameters. The 6MWT was used to assess functional exercise capacity. The maximum amount of oxygen consumed (VO2 max) was calculated. Cardiac parameters and random blood glucose (RBG) were measured pre and post the 6-MWT. Descriptive and inferential statistics were used to analyze the data. p was chosen as the Alpha level < 0.05. There was a decrease in glucose levels post-6MWT in the T2DM group, with a mean and stander deviation pre (260.6±103.9) and post 6MWT (214.3±92.6). Type 2 diabetes patients had a lower functional exercise capacity than healthy controls, with mean and standard deviations of 6MWD and estimated VO2 max of (445.678.7) and (10.91.3) for T2DM and (529.770.1) and (12.31.1) for healthy controls, respectively. Blood glucose control will be enhanced by health education on self-care management, particularly walking. In comparison to matched healthy controls, exercise capacity is reduced in T2DM patients.

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