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05 Jul 2022 (Vol 45 , Iss 05 )

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31 Jul 2022 (Vol 45 , Iss 05 )

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Teikyo Medical Journal


Journal ID : TMJ-21-06-2022-11327
Total View : 407

Title : The Effect Of The Administration Of Minosycline, N-Acetyl Systein And Its Combinations On Aquaporin-4 Expression In The Brain Of Treated Brain Injury Mice

Abstract :

Brain injuries are serious health problems and require appropriate management strategies in the healing process. The purpose of this research was to determine the effect of minocycline and single N-Acetylcysteine compared to the administration of a combination of minocycline or NAC in reducing the expression of Aquaporin-4 (AQP-4) in the brains of experimental animals with brain injuries for seven days after brain injury. The experimental animals were wistar mice (n = 65) that were divided into 5 groups. 1) brain injury treatment and minocycline 45 mg/kg body weight orally (MN), 2) brain injury treatment and NAC 150 mg/kg intraperitoneal (NAC), 3) brain injury treatment and minocycline combination NAC (MCN), 4) brain injury treatment and positive control 0.9% saline 1cc intra peritoneal (PC), and 5) without treatment of brain injury and drug administration (NC). The subjects were observed on days 3, 5 and 7. The repeated measures ANOVA was applied to analyze the data with SPSS v.25. The combination of MN 13.5 mg and NAC 45 mg/kg body weight (4.62, 95% CI 3.40; 5.83 & 6.76, 95% CI 4.90; 8.61 p = 0.00) did not perform better than a single dose of each drug on Aquaporin-4. Moreover, the combination of NAC and Minocycline had no effect on Aquaporin-4 and the administration of a single drug minocycline was found to be better on the 3rd and 5th days, while the administration of NAC was better on the 7th day as shown by the decrease in Aquaporin-4 levels.

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Journal ID : TMJ-19-06-2022-11326
Total View : 447

Title : Diabetes Self-Management among Adult Diabetic Patients Attending a Diabetes Education Clinic in Oman: A cross-sectional study

Abstract :

The increasing prevalence of diabetes mellitus (DM) worldwide represents a global public health emergency. Healthcare professionals play a major role in educating patients regarding important self-care and diabetes management strategies which can help prevent long-term complications. This study aimed to assess knowledge and practice regarding diabetes self-management among patients with type 1 and type 2 DM attending a diabetes education clinic in Oman. In addition, the study aimed to compare levels of knowledge and practice between new referrals and follow-up patients who had received more than two educational sessions. This cross-sectional study was conducted in a tertiary care institution in Muscat, Oman. A total of 181 sequential adult patients who attended the outpatient diabetes clinic between March and October 2018 were included in the study. Participants were categorized into new referrals who had not yet received diabetes education, and follow-up patients who had received more than two educational sessions from the diabetes educator. A previously validated self-administered survey was used to assess levels of knowledge and practice regarding diabetes self-management in the two groups. Of the 181 participants, 61 (33.7%) were newly referred, and 120 (66.3%) were follow-up patients. The mean age was 33.3 ± 12.9 years and 55.8% were female. Overall, 64.1% of the cohort demonstrated excellent knowledge regarding diabetes self-management, while 23.2% and 12.7% had moderate and poor levels of knowledge, respectively. Moreover, 73.5% exhibited satisfactory practices, while inadequate practices were reported by 26.5%. Overall, the diabetes education clinic was effective, with statistically significant differences in knowledge and practice levels noted between the two groups (p = 0.01 and 0.002, respectively). While the whole cohort demonstrated acceptable overall levels of diabetes self-management knowledge and practice, patients who had attended a structured diabetes education program demonstrated substantial improvements in knowledge and behavior compared to the new referrals. As such, specialized diabetes education programs are recommended to help reduce the incidence of acute and chronic complications of DM, thereby reducing the burden of this disease in Oman.

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Journal ID : TMJ-19-06-2022-11324
Total View : 379

Title : The Immunohistochemical Expression of COX-2 and Clinical Parameters in Oral Lichen Planus

Abstract :

Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear etiology. Even though the World Health Organization (WHO) defines OLP as a precancerous condition, the reasons that trigger cancer progression in OLP lesions remain unknown. Cyclooxygenase-2 (COX-2) is an essential enzyme for inflammatory processes and cell proliferation that has been discovered to be overexpressed in OLP lesions in this chronic inflammatory state. The purpose of present research was to determine COX-2 expression levels in histologically identified OLP samples and to correlate it with clinical and histological characteristics. Present study included 30 histopathologically confirmed Oral Lichen Planus lesions. Immunohistochemistry was used to detect COX-2 protein expression. COX-2 expression was compared to certain clinical and histological parameters. The (SPSS) program version (20.0) was utilized to find the relationships between COX-2 expression and these parameters. A Pearson’s correlation between age and sex groups revealed that studies of various age groups revealed a comparable gender distribution with a significant link (P = 0.017). OLP lesions are most commonly found in the buccal mucosa. There is a significant decrease in COX-2 expression was detected in all studied cases of the study. The level of the COX-2 expression rise in correlation with clinical manifestations and cancer development. Through inflammatory reactions, COX-2 is associated with epithelium damage and carcinogenesis pathways.

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Journal ID : TMJ-15-06-2022-11321
Total View : 443

Title : Assessment and Evaluation of Oxidative Stress of Some Enzymatic Antioxidants, Urea and Malondialdehyde in Chronic Hypertensive Pregnants in Basrah Governorate – Iraq

Abstract :

Hypertension disease is one of the biological, biochemical, and physiological disorders which infect most people especially pregnant women. The current research was performed to assess and evaluate the concentrations of glutathione -S – transferase (GST), catalase (CAT), malondialdehyde and urea in blood serum belonging to different hypertensive pregnants in Basrah Governorate – Iraq according to age and embryo sex factors for these pregnants. Catalase recorded a high significant decreasing (p***<0.0001) in all women depending on age and embryo sex of pregnants while GST recorded only a significant decreasing (p**<0.01) in the third age trimester (34-43 years). Urea showed a highly significant increase (p***<0.001) in patients pregnants in the three age trimesters and embryo sex (male and female) whereas malondialdehyde recorded a high significant increasing (p***<0.001) in the first and third age trimesters and significant increasing (p**<0.01) according to embryo sex.

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Journal ID : TMJ-14-06-2022-11316
Total View : 369

Title : Effects of crunch abdominal exercise in the closure of recti abdominis muscles separation in multigravidas: A quasi-experimental study

Abstract :

Diastasis Recti Abdominis (DRA) is a common postpartum condition with predominance women who have undergone multiple pregnancies and births. It is characterized by an abnormal gap between adjacent recti abdominis muscles and weakness of the abdominal segment with impairment of effective trunk function, among other complications. Structured physical exercises have great potentials of resolving DRA with improved muscular strength outcomes. This study evaluated the effects of structured abdominal exercise on the closure of Inter Recti Distance (IRD) among multiparous women. Thirty (30) multiparous women presenting with varying degrees of DRA participated in this quasi-experimental study and were randomly assigned into two groups (experimental – 23 and control – 7). Participants in the experimental group performed isometric abdominal exercises over a four-week period while those in the control group practiced only low-impact jogging exercises. Using the analysis of variance (ANOVA), the exercise group recorded significantly decreased mean IRD at p< 0.05, and also were able to carry out more sustained crunch exercises, when compared to the control group. Within the exercise group, there was also comparative significant increase in mean abdominal muscle strength. The outcome of the study shows that exercises may enhance abdominal muscle strength and potentiate closure of IRD, as well as improve functional activities of daily living in postpartum women.

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