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Teikyo Medical Journal


Journal ID : TMJ-23-03-2022-11211
Total View : 432

Title : Gender Features of Skin Microbiome and Antibiotic Resistance

Abstract :

Sex, as a biological variable, determines immune responses to both self and foreign antigens. Human gender contributes to physiological and anatomical differences that influence the formation of the microbiome. In this regard, this article is aimed at identifying the features of microbial contamination of the skin in students (guys and girls) of the Institute of Natural Science and Medical Institute of Kaluga State University named after K. E. Tsiolkovsky. It was found that the number of microorganisms on the palms and the palmar part of the forearm in girls was 51.2% more than in guys. Most often, actinobacteria, staphylococci, streptococci, and corynebacteria were present. Moreover, the number of corynebacteria on the skin of young men was 1.6 times higher. It was noted that guys were sick more often than girls (except for cystitis), but less often they consulted a doctor for a prescription for antibiotics or used them on their own. Most of the students followed the standard course of antibiotic use or until symptoms disappeared. The most frequently used antibiotics were girls (63%), while guys used antibiotics 1.6 times less often. Only 2% of students never used antibiotics. Most often, students used tetracycline (31.8%), furazolidone (26%), ampicillin (27.8%), lincomycin (16.7%) and clarithromycin (11.1%), azithromycin (12.5%). A diffuse method was used to assess the resistance of microorganisms to antibiotics. The article presents the results of diffuse tests, which showed multi-resistance and gender differences in the resistance of skin microorganisms to antibiotics. The skin microflora of girls is more sensitive to the tested antibiotics than that of guys. Antibiotics to which microorganisms showed resistance were lincomycin (71.4% in guys and 45.3% in girls), fosfomycin (68.57% in guys and 53.85% in girls), benzylpenicillin (51.41% in for boys and 42.2% for girls), oleandomycin (51.43% for guys and 16.2% for girls), doxycillin (40% for guys and 29.1% for girls). The materials of the article are of practical value for understanding the gender characteristics of the skin microbiome and the resistance of microorganisms to antibiotics.

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Journal ID : TMJ-22-03-2022-11210
Total View : 395

Title : The Effect of Curcumin on PFK-1 Glycolytic Enzyme, Inflammatory Bowel Disease and Colon Cancer

Abstract :

Curcumin, from the spice turmeric, has many chemopreventive and chemotherapeutic benefits and has shown promise as an adjuvant treatment for inflammatory bowel disease (IBD) and colorectal cancer (CRC). In this paper we focused on the effect of curcumin upon glycolytic enzymes because in cancer cells glycolysis appears to be the major source of energy. The effects of curcumin upon several glycolytic enzymes were studied with the aim to further define curcumin’s potential for chemoprevention of CRC in IBD patients, whom are known to be at high risk for the development of CRC. We measured rabbit muscle 1-phosphofructokinase (PFK-1), aldolase, enolase, pyruvate kinase (PK), and lactose dehydrogenase (LDH) enzyme activities in the presence of curcumin and compared their enzyme I50 values. We also compared constant concentrations of curcumin with varying enzyme concentrations to determine the enzymes reversibility. We showed reversible inhibition of several glycolytic enzymes with curcumin. We postulate that curcumin may be able to prevent colon cells from acquiring a glycolytic phenotype, prevent cancer cell proliferation through the inhibition of glycolysis, and thereby, prevent the onset of colon carcinogenesis in IBD patients.

Full article
Journal ID : TMJ-22-03-2022-11209
Total View : 366

Title : Nutritional Status And Hydration Status of Pencak Silat Athletes In The Training Unit of Cirebon District, West Java, Indonesia

Abstract :

The optimal amount of nutrients consumed will determine the nutritional status of athletes. Nutrients have a role as an energy source, for the growth of muscle tissue and also support the body's immune system, and play a role in metabolic processes in the body. Nutritional status can support athlete performance. One of the nutrients that play a role in supporting the performance of athletes is fluid which functions to maintain a stable body temperature and maintain acid-base balance in the body. When athletes are dehydrated, they will become dehydrated. Dehydration can not only reduce the performance of athletes, but is also dangerous for the survival of athletes. The aim of the study was to analyze the relationship between nutritional status and hydration status. This type of research is a quantitative research with a cross sectional study design. The research was conducted in the sports building of Sumber Sub-district, Cirebon District, West Java, Indonesia. The research sample was all pencak silat athletes at the coaching stage as many as 30 athletes. The results showed that most of the pencak silat athletes were male (66.7%). The age of the athletes ranged from 16 to 22 years and most of the athletes were less than 19 years old (73.3%). Most athletes have normal nutritional status (76.7%). Some athletes are mildly dehydrated after training (50%). Based on Spearman Rank correlation analysis, it is known that nutritional status is not related to hydration status (p=0.703).

Full article
Journal ID : TMJ-22-03-2022-11208
Total View : 424

Title : Improving Hospital Service Quality of Emergency Department in Pandemic Era: Implementing Integration of Quality Function Deployment (QFD) and Logical Framework Analysis (LFA)

Abstract :

The world is currently facing new challenges with the emergence of COVID-19; during this pandemic, several reports have shown a decrease in the number of visits to health services, the emergency department must be able to develop a design program to improve the quality during the pandemic. This study has aimed to build a quality improvement framework in the emergency department in the pandemic era by implementing Quality Function Deployment (QFD) and Logical Framework Analysis (LFA). This study uses a Mix Method by applying the QFD method, which identifies and analyzes challenges and applies the priorities of the QFD results using LFA to develop a plan. and implementation programs. Analysis of QFD 5 service aspects and 12 technical management responses shows priority from the highest to the lowest for emergency services during a pandemic; based on the results of these priorities, a framework was developed using LFA and obtained a program with goals, objectives, 4 outputs and 12 activities that have indicators and implementation plan. The Conclusion of this research is the integration of quality functions and logical framework analysis is an effective method to identify and analyze challenges from a patient perspective and develop a quality improvement framework, especially in the pandemic era.

Full article
Journal ID : TMJ-20-03-2022-11206
Total View : 400

Title : Assessment OF Sexual Hormones And Their Biochemical Correlation With Lipids profile According To Age And Blood Group Factors In Iraqi Pregnants

Abstract :

The sexual hormones in pregnant women have a strong medicinal and biochemical relationship with lipids profile. The current research was performed on Iraqi pregnant women- Basrah Governorate according to pregnant age and blood group factors. Estrogen, progesterone and testosterone hormones recorded a high significant increase (p <0.0001) with increase of pregnant age whereas concentration of estrogen, progesterone and testosterone hormones showed a highly significant increase (p <0.0001) according to blood group factor. Lipids Profile represented by triglycerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) showed a significant increase in their concentrations according to age and blood group factors. So it was noticed presence of a chemical correlation between sexual hormones and lipids profile depending on age and blood group belonging to pregnants.

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