05 Oct 2022
30 Sep 2022
Pre-eclampsia (PE) is a major complication of pregnancy that could lead to maternal and fetal morbidity and mortality. The analysis of heart rate variability (HRV) is a noninvasive diagnostic tool that provides important information about autonomic functioning and individual’s risk of developing cardiovascular disease. The aim of the present study was to compare the frequency and time domain heart rate variability parameters in pre-eclampsia (PE) with that of normal healthy (NP), as a measure of the autonomic functions. This was a case-control study. Pregnant women diagnosed to have pre-eclampsia according to ACOG guidelines and aged 18-35 years were included as cases. Healthy pregnant women, matched for age, gravida and gestational weeks were included as controls. Gestational age was calculated from first trimester USG. Blood pressure was recorded using a mercury sphygmomanometer (Diamond). Heart rate and heart rate variability (HRV) was recorded by Powerlab (AD instruments). HRV analysis was done in the frequency and time domains. Statistical analysis was done using Student’s t test. There was a significant increase in the systolic and diastolic blood pressures, low frequency (LF) domain, LF/HF ratio and a decrease in high frequency (HF) components of the HRV analysis in pre-eclampsia. The time domain parameters of HRV, SDNN, SDANN, RMSSD and pNN50%, showed a fall in preeclampsia. Sympathetic over activity combined with parasympathetic withdrawal is seen in pre- eclampsia, which may suggest cardiovascular risk in these patients. Autonomic function testing of heart rate variability may be used as a tool for early diagnosis, management and prevention of future cardiovascular diseases in pre-eclampsia women.
Stem cells have an ability to differentiate into many types of cells and have been developed as therapeutic agent in regenerative diseases. Adult tissues such as bone marrow and adipose tissue are source of stem cells that have been developed as therapeutic agent. Recent study reported that stem cells secreted bioactive molecules that have a role in regeneration for tissue repairing. The potency of stem cells secreted factor as an alternative therapeutic agent should be explored. However, aged stem cells were suggested to influence their secreted factors. In this review, selected articles from Pubmed and others additional articles were resumed. Their secreted factor therapy using several types of techniques and terms including “secretome”, “conditioned medium” or “exosome” were extracted. Herewith, we reviewed the source of stem cells, secretome of aged cells, secretome as a novel alternative therapeutic for skin aging, and effect of vitamin C towards their secretome and aging.
COVID-19 starts to spread between the countries since the beginning of 2020 and infects millions of people worldwide. The governments put a strict rule, including lockdown, to prevent the disease; many health consequences happened and got attention from clinicians and researchers. This study aim to assess the severity of anxiety symptoms developed in King Faisal University students by continuous stress and lockdown due to the pandemic (COVID-19). A cross-sectional study was done using the Arabic version of the Hamilton anxiety rating scale, which we apply online, targeting King Faisal University students; the total number of participants was 529. This study showed that 73.2 % of King Faisal University student have mild anxiety symptoms, 14.2 % reported to have mild to moderate anxiety symptoms, while 7.4 % of the students have moderate to severe anxiety symptoms, only a few (5.3%) of the students reported to have very severe anxiety symptoms. The severity of anxiety symptoms significantly related to age, marital status, being a medical college student and smoking. We can conclude that most participants have mild anxiety symptoms while the rest of the participants reported having more severe anxiety symptoms. Age, marital status, smoking and being a medical college student can affect the severity of anxiety symptoms among the population. It is highly recommended to start screening, education and prevention programs for psychiatric impacts among university students and the community as soon as possible since the COVID 19 pandemic is still going.