28 Sep 2022
30 Sep 2022
Condyloma acuminata (CA) is a sexually transmitted infection with a high prevalence associated with psychosexual morbidity in both men and women of various age. Up to now, no treatment modality yields satisfactory clearance and recurrence rate (RR); they are also deemed low quality evidence. Treatment photodynamic therapy (PDT) is a novel and promising therapy to effectively cure and prevent CA recurrence. This systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and registered to the International Prospective Register of Systematic Review (PROSPERO) (CRD42022332760). Ten studies were included in this systematic review. A significant value of complete response (CR) ranging from 63-100% in patients with genital warts after receiving several sessions of PDT. A relatively low recurrence rate was shown in all 10 studies, with an RR of less than 17%. Quality assessment of included studies reported mostly high-quality research. PDT therapy resulted in a higher CR with significantly lower RR compared to other therapies. Thus, PDT can be an alternative treatment of CA with a low RR and minimal side effects. Additional research, especially randomized clinical trials in various countries, is recommended to further substantiate this treatment.